Industry Publications

RNAi Delivery – Self-delivering RNAi compounds
Cardia J, Samarsky D, Woolf T. (2010) Drug Delivery Technology.
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Peer-Reviewed Publications

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain 
Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A. (2015) Molecular Therapy Nucleic Acids. 
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Exosomes are natural carriers of exogenous siRNA to human cells in vitro
Shtam TA, Kovalev RA, Varfolomeeva EY, Makarov EM, Kil YV, Filatov MV. (2013) Cell Communication and Signaling. 
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Novel hydrophobically modified asymmetric RNAi compounds (sd-rxRNA) demonstrate robust efficacy in the eye
Byrne M, Tzekov R, Wang Y, Rodgers A, Cardia J, Ford G, Holton K, Pandarinathan L, Lapierre J, Stanney W, Bulock K, Shaw S, Libertine L, Fettes K, Khvorova A, Kaushal S, Pavco P. (2013) Journal of Ocular Pharmacology and Therapeutics.
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Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs 
Osborn MF, Alterman JF, Nikan M, Cao, H, Didiot MC, Hassler MR, Coles AH, Khvorova A. (2015) Nucleic Acids Research.
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A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo
Coles AH, Osborn MF, Alterman JF, Turanov AA, Godinho BM, Kennington L, Chase K, Aronin N, Khvorova A. (2016) Nucleic Acid Therapeutics.
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